The lycanthropy disease, also known as werewolfism, the curse, simply as lycanthropy, or a myriad of other names, is a disease caused by an unknown agent that is spread by a werewolf vector and apparently causes symptomatic effects only in humans. The origin of the agent is hypothesized to be a virus that is unlike any known to modern medical science, resulting extreme morphisms and behavioral changes in the patient. Lycanthropy may possibly be supernatural in origin. Contrary to supernatural folklore, a person who is infected with lycanthropy and has transformed into a werewolf is not immortal and can be killed with standard ways that can kill regular humans (gunshots, severe blunt damage by a van, impaling by a knife, etc).



Mechanism[edit | edit source]

The disease appears supernatural in origin, but the agent is possibly a virus (note, however, that a virus that could be a candidate for being the lycanthropy agent has not yet been isolated from patients). The method of transmission is from werewolves to humans. Lycanthropy is only spread through bites, possibly scratches, and does not exhibit airborne or droplet transmission ability, meaning that the virus could concentrate in the victim's saliva as in rabies. However, transmission over the course of the werewolf transformation is unknown: does infectivity increase as an infected person develops more werewolf qualities?

The virus gradually affects the body, first by minor physical changes and behavior changes, then a rapid transformation into a werewolf. Interestingly, the lycanthopy disease may have a correlation with the full moon cycle, where if a person is infected on a day not on a full moon, full transformation takes place at the next full moon. In addition, the disease exhibits latent effects which may correspond to the full moon (where the closer to the full moon, the more the disease takes effect- otherwise, the patient may be asymptomatic if several days away from the next full moon).


Signs and Symptoms[edit | edit source]

Transformation appears to be a rapid process overall. There is no formal diagnostic criteria for lycanthropy; however, listed are all signs and symptoms seen in patients. Frequency is unknown because of the small sample size. It is important to note that signs and symptoms of infection vary widely among humans and between the sexes of males and females, but typically start off slowly with smaller physical and mental changes, which accelerate into larger changes. Lycanthropy apparently is irreversible and ultimately results in a complete transformation from human to werewolf in 100% of all people affected. There is no known cure; however, monkshood is an experimental treatment for slowing down the disease progression.

Known Signs and Symptoms of Lycanthropy
Minor Sign & Symptom Observations Disease Description Major Sign and Symptom Observations Disease Description
Hypertrichosis Overgrowth of hair Compulsive sexual behavior (Hypersexuality) Increased libido and risky sexual activities
Hematuria Blood presence in urine Leukotrichia Whitening of hair
Hypomania Persistent disinhibition (lack of restraint) and mood elevation (euphoria) Hallucinations A perception of having seen, heard, touched, tasted, or smelled something that wasn't actually there
Menorrhagia (in women) Heavy menstruation Delusions
  • Megalomania
Delusions: belief or altered reality that is persistently held despite evidence or agreement to the contrary


Megalomania: delusions of grandeur

Vasovagal syncope Fainting or passing out Sadism
  • Zoosadism
Sadism: deriving pleasure from harming others

Zoosadism: deriving pleasure from harming/killing animals

Agitation (restlessness) Inability to rest Edentulism followed by polyodontia (with canine teeth) Edentulism: loss of teeth

Polyodontia: excess presence/growth of teeth

Emesis Action of vomiting Proteus syndrome Severe disfigurement from hypertrophy and hyperplasia of tissues
Sleeplessness Minor disturbance in sleep patterns, inability to fall asleep Splanchnomegaly (uncertain if occurs in lycanthropy) Abnormal enlargement of organs
Parasomnia Frequent nightmares and anxiety from sleeping Mania Extremely elevated and excitable mood
Hyperonychia Overgrowth (hypertrophy) of nails Insomnia (uncertain if occurs in lycanthropy) Persistent problems falling and staying asleep
Acne vulgaris Known as common acne, a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair follicles Regeneration and accelerated healing Regeneration: regrowth of lost body parts/organs
Hyperacuity of the senses
  • Visual hyperacuity
  • Hyperacusis
  • Tactile hypersensitivity
  • Gustatory hypersensitity
  • Hyperosmia
Excess augmentations (increases) in vision, hearing, touch, taste, and smell, respectively
Photophobia (uncertain if occurs in lycanthropy) Intolerance of bright lights, especially flashes
Schizoaffective disorder (uncertain if occurs in lycanthropy, and disorder is diagnosed by the following combination of signs and symptoms)
  • Delusions
  • Hallucinations
  • Depression
  • Mania
See disease symptoms with definitions above. Disorder is characterized by cycles of severe symptoms followed by periods of improvement
Progeria (uncertain if occurs in lycanthropy) Accelerated aging
Aggression Form of physical or verbal behavior leading to self-assertion
Hypermetabolism (uncertain if occurs in lycanthropy) Elevated resting energy expenditure
Heterochromia iridum (imprecise term for changing eye colors seen in lycanthropy patients) Differences in iris eye color
Neoplastic growth Development of tumors
Gigantism (in children) and acromegaly (in adults) Overgrowth of limbs and facial features due to excess hormone production


Known minor and moderate changes include hypertrichosis (an overgrowth of hair), hematuria (blood in urine), hypomania, and for women, menorrhagia (heavy menstruations). Lycanthropy- slowly at first then rapidly- progresses to major and severe changes, including hypersexuality, leukotrichia (whitening of the hair), hallucinations, megalomania, zoosadism (causing harm to animals), and edentulism (loss of teeth) followed by polyodontia (increased number of teeth- in this case, the growth of canine teeth).

Uncertain conditions include photophobia, progeria, and splanchnomegaly.

Treatment[edit | edit source]

There does not appear to be a permanent cure. Palliative care is necessary, and only a temporary treatment that delays the lycanthropy disease is available. Monkshood appears to be a viable way to slow the effects of lycanthropy; Brigitte Fitzgerald times her injury healing rate, which, despite her using of regular doses of monkshood, accelerates, meaning that the monkshood cure effects decline in effect over time. However, it appears that if intervention is not used, then the body rejects further doses of monkshood and no longer works.


References[edit | edit source]

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